TERMS Trial Timeline.

• Wed 9/13/2006 Last Rebif injection!
• Fri 9/15/06 Signed consent forms at Dr. for Tovaxin trial.
• Tues 10/31/2006 Vial blood draw for MRTC’s --Negative.
• Fri 12/8/2006 2^nd Vial blood draw for MRTC’s. --Positive EDSS 3.0.
• Wed 1/17/2007 Blood draw to make vaccine. MRI.
• 3/2/2007 started a bad relapse.
• 3/8/07 Saw local neurologist about bad relapse.
• 3/8-3/10 2007 received 3 day course of IV Solu-Medrol, 1gram per day without oral taper. 30 days until re-evaluation to see if this made me stable.
• Mon 3/12/2007 received the useless MRI in Los Alamos.
• Fri 3/16/2007 Saw Dr. EDSS 5.0.
• Wed 3/28/2007 10 weeks since blood draw to make vaccine.
• Mon 4/9/2007 30 day mark since last infusion.
• Tues 4/10/07 Dr. found me stable. EDSS back to 3.0. Vaccine ordered from Opexa. Was told I will get MRI, tests, blood, pee, and vaccine!?! 5/3/2007.
• 5/3/07 received first ‘Tovaxin’ shot @13:09. Did MRI, peg test, math test, MSQLI, speed walk test, pee, and 19? vials of blood. EDSS 3.0. (Visit 4)
• 5/9/07 Second ‘Tovaxin’ shot scheduled 6/7/07. Told no MRI.
• 5/17/07 Opexa announced the 150 patients needed have now been enrolled.
• 6/7/07 received second ‘Tovaxin’ shot @11:56 No MRI, peg test, math test, speed walk test, pee, and 13 vials of blood. (Week 4/Visit 6) EDSS 3.5
• 6/11/07 Trial coordinator said the study monitor inquired about allergies.
• Third ‘Tovaxin’ shot scheduled for 7/6/07. 10am MRI check in, 13:30 appt at Dr.
• 7/6/07 10:00 MRI 13:30 appt at Dr. Did MRI, peg test, math test, speed walk test, pee, and 13 vials of blood. Received third ‘Tovaxin’ shot@ 14:16 EDSS 3.5.
• Forth ‘Tovaxin’ shot scheduled for 8/3/07. 10am MRI check in, 13:15 appt at Dr.
• 8/3/07 10:00 MRI 13:15 appt at Dr. Did MRI, peg test, math test, speed walk test, pee, MSQLI, and 13 vials of blood. Received forth ‘Tovaxin’ shot@ 14:30 EDSS 3.5.
• Saw Dr. 10/12/07 at 13:30 about a difficulties in gait since 10/1/07. Got even worse 10/8/07, Recommended Solu-Medrol treatments. EDSS 6.0, Got infusions 500mg b.i.d., 10/16 – 10/18, Solu-Medrol pack for 6 days following this. Last pill taken 10/24/07.
• Fifth, and last, ‘Tovaxin’ 10/25/07. Peg test, math test, speed walk test, pee, no MRI, 13:15 appt at Dr. EDSS 4.0. 12.5 Vials draw was a hard draw due to Solu-Medrol infusions, 6 sites. Normally give 13 vials.
• Dr. 11/20/07 1:45, MRI 11/21/07 at 11:00 13 Vials of blood, easier this time. . Peg test, math test, speed walk test, pee. EDSS 3.5.
• Dr. 1/18/08 13:00, MRI at 15:00. 13 Vials of blood, much easier this time. Peg test, math test, speed walk test, MSQLI, and pee. EDSS 3.5.
• ‘Spinal Event’ 2/12/08 a.m.
• Dr. 3/14/08 13:00, MRI 15:00. 13 Vials of blood. Peg test, math test, speed walk test and pee. EDSS 3.0
• Last Phase IIb Visit Friday 5/9/08. 13:00.
• Friday 5/9/08 Last Phase IIb Visit, First ext. study visit. Did MRI, peg test, math test, speed walk test, pee, MSQLI, and 13 vials of blood. EDSS 2.0!?!
• 5/27/08 Received notice I’m MRTC positive from 5/9/08 appt. awaiting blood draw appt.
• 7/2/08 Opexa called for med. survey, said Life Blood Biologic would call within a week for the big blood draw appt.
• 7/17/08 2pm Blood procurement to make vaccine.
• 9/10/08 Got call that vaccine ready.
• Made appt. for 10/10/08 1:30pm appt to receive 1^st vaccine.
• 9/16/08 appt for vaccine delayed indefinitely due to hurricane Ike’s impact on Houston.
• 9/25/08 Made new date for first shot, 10/24/08 1:30pm
• 9/31/08 Found out I was on Tovaxin during the study.